When I was completing my post-doc at Uniformed Services University, I reviewed data on weight regain after stopping a diet. This was called weight cycling and was a very common phenomenon due to biological, psychological, behavioral, and environmental factors. Today GLP medications are a powerful tool for weight loss, but an important clinical question remains: what happens when these medications are stopped? Does the weight cycling phenomenon that I reviewed exist with GLP users? Spoiler alert….yes, it does.